Drug Standards
Medchemexpress LLC Tyloxapol | 25301-02-4 | 10 G
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, functioning as a surface active stabilizer. It is utilized to induce hyperlipidemia in animals, characterized by high levels of plasma triglycerides and LDL-cholesterol, and reduced HDL-cholesterol. It can increase plasma cholesterol levels by promoting hepatic cholesterol synthesis and disturbing lipolytic enzymes, blocking lipid uptake from circulation.
- Used to induce hyperlipidemia in animals
- Triggers detachment of HEK293 cells
- Induces nuclear fragmentation and apoptotic nuclei
- Increases risk of pulmonary hemorrhage and causes cytotoxicity
- Reduces AChE and MAO enzyme activities in rat plasma and brain
- Leads to reduction in plasma urea, creatinine, and bilirubin
- Appearance: liquid
- Color: colorless to light yellow
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | MFCD00866007 | 99.9% | 1 ML
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid that acts as a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. It exhibits little to no activity at other steroid receptors and also possesses anti-viral activity. This product is intended for research use only.
- Available as solid and a 10 mM solution in DMSO.
- Shipped at room temperature within the continental US.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Soluble in DMSO at 100 mg/mL (199.77 mM).
- Insoluble in H2O.
Apexbio Technology LLC Moxifloxacin(Synonyms: Avelox, Vigamox, Avalox, Moxeza, Proflox, Octegra, MXF, BAY 12-8039), 200mg, CAS: 151096-09-2.
Moxifloxacin (CAS 151096-09-2) is a fluoroquinolone antibiotic targeting bacterial DNA gyrase an enzyme essential for DNA replication and transcription It demonstrates broad-spectrum antibacterial activity through inhibition of this enzyme Research indicates that Moxifloxacin exerts dose-dependent antiproliferative and cytotoxic effects in mammalian cell models with concentrations between 50 and 1500 g/mL significantly impacting cell viability and inducing morphological damage such as binucleation Animal studies show intravenous administration (100 mg/kg rats) elevates blood glucose and serum adrenaline levels accompanied by enhanced histamine release but no effect was noted at 75 mg/kg Therefore Moxifloxacin is valuable in biomedical studies exploring antibiotic toxicity cellular proliferation and metabolic responses
Medchemexpress LLC Iodixanol | 92339-11-2 | 100.0% | 100 MG
Iodixanol is an iodine-containing non-ionic radiocontrast agent for research use only. It is not sold to patients.
- Exhibits less kidney toxicity.
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 100 MG
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission.
- IC50 & Target: D2 Receptor
- Shows KDs of 25, 190, and 8400 nM at the human norepinephrine transporter, serotonin transporter, and dopamine transporter respectively in vitro
- Molecular weight: 320.88
- Formula: C17H21ClN2S
- CAS number: 53-60-1
- Appearance: Solid
- Color: White to off-white
Cayman Chemical Itraconazole 50mg
An antifungal agent and hedgehog pathway inhibitor; inhibits hedgehog signaling (IC50 = 0.8 μM); binds to 14-α sterol demethylase/CYP51 isoform B (Kd = 31 nM for A. fumigatus enzyme expressed in E. coli); inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after 16 hours); inhibits C. neoformans growth by 50% at 3.2 nM; suppresses growth of medulloblastomas in a Ptch+/-p53-/- mouse allograft model at 100 mg/kg twice daily; reduces viral titers of several enteroviruses in infected cells from 1.25-100 µM
Cayman Chemical Glycyrhza glabra Acarbose 1g
An inhibitor of α-glucosidases (IC50s = 0.16 and 2.9 µM for maltase and sucrase, respectively); activates phosphorylase kinase in a cell-free assay at 250 µM; decreases urine levels of glucose and glycosylated hemoglobin, as well as glomerular mesangial thickening in a db/db mouse model of diabetic nephropathy at 40 mg/kg in the diet; reduces sucrose-induced increases in infarct size as a percentage of the area at risk and serum MDA levels in a mouse model of coronary artery ligation-induced cardiac ischemia-reperfusion injury at 10 mg/kg
Medchemexpress LLC Diltiazem | 42399-41-7 | 99.7% | 500 MG
Diltiazem is an orally active L-type Ca2+ channel blocker. It exhibits antihypertensive and antiarrhythmic effects and is utilized in research for cardiac arrhythmia, hypertension, and angina pectoris.
- Acts as an L-type calcium channel blocker
- Shows antihypertensive and antiarrhythmic effects
- Useful for cardiac arrhythmia research
- Applicable for hypertension and angina pectoris research
- Demonstrated antiproliferative activity in certain cell lines
- Inhibits P-glycoprotein-mediated multidrug resistance
- Prevents aortic aneurysm formation in animal models
Medchemexpress LLC Triamcinolone (Standard) | 124-94-7 | MFCD00010477 | 98.02% | 100 MG
Triamcinolone (Standard) is an analytical reference standard used for research and analytical applications. This product is suitable for qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Intended for research and analytical applications
- Used as an analytical standard
- Suitable for qualitative research experiments
- Suitable for quantitative research experiments
- Suitable for methodological research experiments
- Compatible with HPLC
- Compatible with GC
- Compatible with MS
Apexbio Technology LLC Triamcinolone Acetonide 76-25-5 10mM (in 1mL DMSO)
Triamcinolone acetonide is a synthetic glucocorticoid steroid characterized by potent anti-inflammatory activity Its molecular structure allows it to penetrate cells effectively facilitating modulation of inflammatory processes by suppressing IgE-dependent histamine release from human basophils This effect interferes with mast cell-mediated allergic response pathways reducing inflammation in affected tissues Additionally Triamcinolone acetonide inhibits proliferation of specific human cell lines including the NEL-M1 melanoma cells making it particularly useful in oncology research settings involving cell growth regulation It is widely applied in biomedical investigation for studying inflammatory signaling pathways immune cell functions and cellular proliferation mechanisms relevant to dermatological autoimmune and tumor-associated inflammatory conditions
Medchemexpress LLC Amoxicillin | 26787-78-0 | 99.9% | 1 G
Amoxicillin is an antibiotic with good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, which in turn inhibits cell growth. It is intended for research use only.
- Good oral absorption
- Broad-spectrum antimicrobial activity
- Inhibits biosynthesis of polypeptides in the cell wall
- Inhibits cell growth
- Intended for research use only
Apexbio Technology LLC Ivermectin 70288-86-7 10mM (in 1mL DMSO)
Ivermectin is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors ( 7 nAChR) and purinergic receptors (P2X4) Additionally ivermectin influences chloride ion channels regulated by glutamate and GABA and also enhances glycine receptor-mediated currents at low concentrations It is commonly employed in neuropharmacological research examining receptor function ion channel activity and neurotransmitter signaling pathways As an anthelmintic ivermectin is widely used in parasitology research for its inhibition of parasite neuromuscular transmission Reported IC50 values vary among receptor types generally ranging from nanomolar to micromolar levels depending on assay conditions and biological context
Apexbio Technology LLC Isradipine (Dynacirc)(Synonyms: Dynacirc, Prescal, Lomir, PN 200-110, Isrodipine, (+/-)-Isradipine, Isradipex), 10mM (in 1mL DMSO), CAS: 75695-93-1.
Isradipine (Dynacirc CAS 75695-93-1) is a small molecule antagonist belonging to the dihydropyridine class of calcium channel blockers It functions primarily by inhibiting L-type voltage-gated calcium channels thereby decreasing intracellular calcium influx into cardiac and vascular smooth muscle cells This inhibitory effect relaxes vascular smooth muscle tissue leading to vasodilation and subsequent reduction in systemic blood pressure In biomedical research isradipine is studied for its potential neuroprotective properties related to calcium-mediated excitotoxicity offering implications for conditions associated with neuronal calcium imbalance
Apexbio Technology LLC Cabozantinib (XL184, BMS-907351) 849217-68-1 100mg
Cabozantinib (XL184 BMS-907351 CAS 849217-68-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) notably VEGFR2 MET and RET with reported IC50 values of 0 035 nmol/L 1 3 nmol/L and 5 2 nmol/L respectively Acting by blocking downstream phosphorylation events cabozantinib disrupts RTK-mediated cell signaling pathways fundamental to cellular proliferation and differentiation In vitro studies utilizing RET-mutant TT cells showed dose-dependent inhibition of RET autophosphorylation (IC50 85 nmol/L) and reduced cellular proliferation In vivo experiments using TT-cell xenograft mouse models demonstrated tumor growth suppression and decreased serum calcitonin levels Cabozantinib serves as a valuable tool in oncology and RTK-related signaling research